| Pair Name | Daidzein, Gefitinib | ||
| Phytochemical Name | Daidzein (PubChem CID: 5281708 ) | ||
| Anticancer drug Name | Gefitinib (PubChem CID: 123631 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Daidzein, Gefitinib | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Activity | ROS1 | hsa6098 |
| Up-regulation | Activity | MAP3K5 | hsa4217 | |
| Up-regulation | Activity | MAPK8 | hsa5599 | |
| Up-regulation | Activity | JUN | hsa3725 | |
| Down-regulation | Expression | EGFR | hsa1956 | |
| Down-regulation | Expression | SOAT1 | hsa6646 | |
| Down-regulation | Expression | AKT1 | hsa207 | |
| Down-regulation | Expression | MAPK1 | hsa5594 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| In Vivo Model | 4×10⁶ A549 cancer cells in Matrigel serum free medium (BD Biosciences) suspension were subcutaneously injected into 8-week-old male NU/NU mice hind legs. | |||
| Result | Daidzein Synergizes with Gefitinib to Induce ROS/JNK/c-Jun Activation and Inhibit EGFR-STAT/AKT/ERK Pathways to enhance Lung Adenocarcinoma cells chemosensitivity | |||
| No. | Title | Href |
|---|---|---|
| 1 | Daidzein Synergizes with Gefitinib to Induce ROS/JNK/c-Jun Activation and Inhibit EGFR-STAT/AKT/ERK Pathways to enhance Lung Adenocarcinoma cells chemosensitivity. Int J Biol Sci. 2022 May 16;18(9):3636-3652. doi: 10.7150/ijbs.71870. | Click |
